منابع مشابه
Lumens laid out by PAR-1
he plasma membrane polarizes in moving cells by reorganizing lipid rafts, according to Gómez-Moutón et al. on page 759. This polarization puts migration tools at the correct end of the cell. The polarization of signaling molecules such as PI3K allows migrating cells to respond directionally to chemo-tactic signals by forming lamellipodia at the front and uropods at the rear. Gómez-Moutón et al....
متن کاملCardiovascular responses mediated by protease-activated receptor-2 (PAR-2) and thrombin receptor (PAR-1) are distinguished in mice deficient in PAR-2 or PAR-1.
We developed mice deficient in protease-activated receptor-2 (PAR-2) or PAR-1 to explore the pathophysiological functions of these receptors. In this report, we evaluated mean arterial pressure and heart rate (HR) changes in response to PAR-1 or PAR-2 activation in anesthetized wild-type (WT), PAR-1-deficient (PAR-1(-/-)), and PAR-2-deficient (PAR-2(-/-)) mice. In WT mice, TFLLRNPNDK, a PAR-1 s...
متن کاملOut of Work and Out of Luck? Layoffs, System Justification, and Hiring Decisions for People Who Have Been Laid Off
Are hiring decisions affected by knowledge that a job applicant was previously laid off? We expected decisional biases to be linked with the motivational tendency to believe that society is fair and outcomes are just and deserved (hereafter, system justifying beliefs [SJBs]). Indeed, hiring decisions were more likely to disadvantage a laid off applicant as SJBs increased both when detailed job ...
متن کاملPar-1 regulates bicoid mRNA localisation by phosphorylating Exuperantia.
The Ser/Thr kinase Par-1 is required for cell polarisation in diverse organisms such as yeast, worms, flies and mammals. During Drosophila oogenesis, Par-1 is required for several polarisation events, including localisation of the anterior determinant bicoid. To elucidate the molecular pathways triggered by Par-1, we have performed a genome-wide, high-throughput screen for Par-1 targets. Among ...
متن کاملNeural crest specification by noncanonical Wnt signaling and PAR-1.
Neural crest (NC) cells are multipotent progenitors that form at the neural plate border, undergo epithelial-mesenchymal transition and migrate to diverse locations in vertebrate embryos to give rise to many cell types. Multiple signaling factors, including Wnt proteins, operate during early embryonic development to induce the NC cell fate. Whereas the requirement for the Wnt/β-catenin pathway ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2004
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb1645iti2